Toluene → Ethyl 4-[(2-fluorophenyl)-hydroxy-phenylmethyl]piperidine-1-carboxylate

HRID 2339177Notes

Reaction equation

HRID 2339177 reaction equation
[C:30]([O:31][CH2:32][CH3:33])(=[O:34])[Cl:35].[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][c:42]1[CH3:43].[F:1][c:2]1[c:3]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:4][cH:5][cH:6][cH:7]1>>[F:1][c:2]1[c:3]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][N:13]([C:30]([O:31][CH2:32][CH3:33])=[O:34])[CH2:14][CH2:15]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 7237O-XyleneHCID 10928Ethyl chloroformateHCID 23326065alpha-(2-Fluorophenyl)-1-methyl-alpha-phenyl-4-piperidinemethanol

Product 1

HCID 53875999Ethyl 4-[(2-fluorophenyl)-hydroxy-phenylmethyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8758f8d04a4747ca93a12c832137ec21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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