Dichloromethane → 4-(4-(7-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-methylpiperazine-1-carboxamide

HRID 2339399Notes

Reaction equation

HRID 2339399 reaction equation
[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[CH3:51][N:52]=[C:53]=[O:54].[Cl:55][CH2:56][Cl:57].[F:1][c:2]1[cH:3][c:4]([NH:31][C:32](=[S:33])[NH:34][C:35]([CH2:36][c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)=[O:43])[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16](-[c:18]1[cH:19][cH:20][c:21]([CH2:24][N:25]3[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]3)[cH:22][cH:23]1)[s:17]2>>[F:1][c:2]1[cH:3][c:4]([NH:31][C:32](=[S:33])[NH:34][C:35]([CH2:36][c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)=[O:43])[cH:5][cH:6][c:7]1[O:8][c:9]1[c:10]2[c:11]([n:12][cH:13][cH:14]1)[cH:15][c:16](-[c:18]1[cH:19][cH:20][c:21]([CH2:24][N:25]3[CH2:26][CH2:27][N:28]([C:53]([NH:52][CH3:51])=[O:54])[CH2:29][CH2:30]3)[cH:22][cH:23]1)[s:17]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 59457695N-(3-Fluoro-4-(2-(4-(piperazin-1-ylmethyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Product 1

HCID 167179204-(4-(7-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-methylpiperazine-1-carboxamide

Sources & evidence

ORD record
ord-e47dceb4fc18493691246c4555d734e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…