Tetrahydrofuran → 1-methyl-4-(2-trityl-2,3-dihydro-1H-isoindol-5-yl)-piperidin-4-ol
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][N:6]([C:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[CH2:5]2.[CH2:30]([Li:31])[CH2:32][CH2:33][CH3:34].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:35][N:36]1[CH2:37][CH2:38][C:39](=[O:42])[CH2:40][CH2:41]1>>[c:2]1([C:39]2([OH:42])[CH2:38][CH2:37][N:36]([CH3:35])[CH2:41][CH2:40]2)[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][N:6]([C:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[CH2:5]2Participants
5
Sources & evidence
- ORD record
- ord-b45d3de312204c228ed39f96ef4e13e8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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