Dichloromethane → Taladegib

HRID 2339790Notes

Reaction equation

HRID 2339790 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][N:6]([c:9]2[n:10][n:11][c:12](-[c:19]3[cH:20][cH:21][n:22][n:23]3[CH3:24])[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[CH2:7][CH2:8]1.[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[Cl:46][CH2:47][Cl:48].[F:32][c:33]1[cH:34][c:35]([C:42]([F:43])([F:44])[F:45])[c:36]([C:37](=[O:38])[Cl:39])[cH:40][cH:41]1>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([c:9]2[n:10][n:11][c:12](-[c:19]3[cH:20][cH:21][n:22][n:23]3[CH3:24])[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[CH2:7][CH2:8]1)[C:37]([c:36]1[c:35]([C:42]([F:43])([F:44])[F:45])[cH:34][c:33]([F:32])[cH:41][cH:40]1)=[O:38]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 6056804-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 59627388N-methyl-1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-amine

Product 1

HCID 49848070Taladegib

Sources & evidence

ORD record
ord-3b10e630d5a14602a4f0ad8a87112b5a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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