Dichloromethane → Ethyl 5-(3-aminophenyl)isoxazole-3-carboxylate

HRID 2340176Notes

Reaction equation

HRID 2340176 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][o:8][c:9](-[c:11]2[cH:12][c:13]([NH:17][C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[cH:14][cH:15][cH:16]2)[cH:10]1.[CH2:32]([Cl:33])[Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][o:8][c:9](-[c:11]2[cH:12][c:13]([NH2:17])[cH:14][cH:15][cH:16]2)[cH:10]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 49775748Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate

Product 1

HCID 44819012Ethyl 5-(3-aminophenyl)isoxazole-3-carboxylate

Sources & evidence

ORD record
ord-40a81093915745aa802e5de0baf3a22b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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