Ethanol → (RS)-2-amino-2-(3-bromo-phenyl)-2-(4-difluoromethoxy-3-methyl-phenyl)-ethanol

HRID 2340684Notes

Reaction equation

HRID 2340684 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]2([c:14]3[cH:15][c:16]([CH3:24])[c:17]([O:20][CH:21]([F:22])[F:23])[cH:18][cH:19]3)[NH:9][C:10](=[O:13])[O:11][CH2:12]2)[cH:5][cH:6][cH:7]1.[CH3:25][CH2:26][OH:27].[Li+:28].[OH-:29].[OH2:30]>>[Br:1][c:2]1[cH:3][c:4]([C:8]([NH2:9])([CH2:12][OH:11])[c:14]2[cH:15][c:16]([CH3:24])[c:17]([O:20][CH:21]([F:22])[F:23])[cH:18][cH:19]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961HydroxideHCID 962WaterHCID 28486Lithium ionHCID 681534954-(3-Bromo-phenyl)-4-(4-difluoromethoxy-3-methyl-phenyl)-oxazolidin-2-one

Product 1

HCID 68153498(RS)-2-amino-2-(3-bromo-phenyl)-2-(4-difluoromethoxy-3-methyl-phenyl)-ethanol

Sources & evidence

ORD record
ord-6d8e0347168049b2b2d693a49cc6b967
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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