反应详情

To a solution of methyl 3-(2-bromophenyl)propionate (35.77 g) in ethanol (80.7 ml) was added at room temperature dropwise a solution of sodium hydroxide (11.77 g) in water (40 ml). After the reaction mixture was stirred under reflux for 2.5 hrs. and left standing for cooling, methanol was removed by distillation under reduced pressure, the residue was poured into ice-hydrochloric acid and stirred for 20 minutes. Crystalline precipitates were filtered, washed well with water, dried under reduced pressure to give the title compound (32.4 g).

1. temperatureunder reflux for 2.5 hrs
2. waitand left standing
3. temperaturefor cooling
4. custommethanol was removed by distillation under reduced pressure
5. additionthe residue was poured into ice-hydrochloric acid
6. stirringstirred for 20 minutes
7. customCrystalline precipitates
8. filtrationwere filtered
9. washwashed well with water
10. customdried under reduced pressure