反应详情

To a solution of the crude 4-bromo-1-indanol (1.02 g) in dimethylformamide (10 ml) were added at an ice temperature imidazole (0.645 g) and tert-butyldimethylsilyl chloride (0.857 g). The reaction mixture was stirred at the same temperature overnight, poured into a saturated aqueous saline solution and extracted with ether. The organic layer was washed with a saturated aqueous saline, dried over sodium sulfate, and the solvent was removed by distillation under reduced pressure. The residual concentrate (1.6 g) was purified by chromatography on a silica gel column to give the title compound (1.51 g).

1. additionpoured into a saturated aqueous saline solution
2. extractionextracted with ether
3. washThe organic layer was washed with a saturated aqueous saline
4. dry with materialdried over sodium sulfate
5. customthe solvent was removed by distillation under reduced pressure
6. concentrationThe residual concentrate (1.6 g)
7. customwas purified by chromatography on a silica gel column