Hexamethyldisilazane → HCID 178504300, compound

HRID 234103Notes

Reaction equation

HRID 234103 reaction equation
[NH:1]1[CH:8]=[CH:7][C:5](N)=[N:4][C:2]1=[O:3].[CH3:9][Si:10]([CH3:17])([CH3:16])[NH:11][Si:12]([CH3:15])([CH3:14])[CH3:13].S([O-])([O-])(=O)=O.[NH4+].[NH4+]>ClCCl>[CH3:9][Si:10]([N:11]([Si:12]([CH3:15])([CH3:14])[CH3:13])[C:8]1[CH:7]=[CH:5][NH:4][C:2](=[O:3])[N:1]=1)([CH3:17])[CH3:16]

Participants

5

Reactant 3

HCID 13838HexamethyldisilazaneHCID 6097028Ammonium SulfateHCID 178418229Cytosine

Product 1

HCID 178504300HCID 178504300, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
23 °C

Procedure

To 5.78 g of cytosine were added 112 ml of hexamethyldisilazane and 50 mg of ammonium sulfate. This solution was heated to 115° C.-120° C. for 2 hours with stirring and the excess hexamethyldisilazane was subsequently removed. The resulting oil was cooled to 23° C. to form a solid residue which was reconstituted in 35 ml of dichloromethane to form a homogenous bis-trimethylsilylcytosine solution and cooled to 0° C.

Workup

  1. temperatureThis solution was heated to 115° C.-120° C. for 2 hours
  2. customthe excess hexamethyldisilazane was subsequently removed
  3. customto form a solid residue which

Sources & evidence

ORD record
ord-6fd5e336398944629462b0c30aaaf8b0
Source dataset
uspto-grants-1997_01
Patent number
US05594124

Reaction notes

Loading…