Di-t-butyl[[4-[[N-[3-(1-t-butyloxycarbonylpiperidin-4-yl)propionyl]amino]acetyl]-o-phenylene]dioxy]diacetate → {2-Carboxymethoxy-5-[2-(3-piperidin-4-yl-propionylamino)-acetyl]-phenoxy}-acetic acid

HRID 234135Notes

Reaction equation

HRID 234135 reaction equation
C([C:5](C(C)(C)C)([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:36])[CH2:17][NH:18][C:19](=[O:35])[CH2:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]2)=[CH:12][C:11]=1[O:37][CH2:38][C:39]([O-:41])=[O:40])[C:6]([O-:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[NH:25]1[CH2:26][CH2:27][CH:22]([CH2:21][CH2:20][C:19]([NH:18][CH2:17][C:16]([C:13]2[CH:14]=[CH:15][C:10]([O:9][CH2:5][C:6]([OH:8])=[O:7])=[C:11]([O:37][CH2:38][C:39]([OH:41])=[O:40])[CH:12]=2)=[O:36])=[O:35])[CH2:23][CH2:24]1

Participants

3

Reactant 1

HCID 21465935Di-t-butyl[[4-[[N-[3-(1-t-butyloxycarbonylpiperidin-4-yl)propionyl]amino]acetyl]-o-phenylene]dioxy]diacetate

Product 1

HCID 44321683{2-Carboxymethoxy-5-[2-(3-piperidin-4-yl-propionylamino)-acetyl]-phenoxy}-acetic acidYield 118.6%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The compound prepared in (a) (480 mg) was dissolved in 5 ml of trifluoroacetic acid and treated in the same manner as described in Example 9 (b) to give the title compound (380 mg).

Workup

  1. additiontreated in the same manner

Sources & evidence

ORD record
ord-70f894acbd5348dbb915a7d4afacbeef
Source dataset
uspto-grants-1997_01
Patent number
US05594004

Reaction notes

Loading…