Borane → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

HRID 2341353Notes

Reaction equation

HRID 2341353 reaction equation
[BH3:17].[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:12](=[O:13])[OH:14])[CH2:15][CH2:16]1.[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][OH:13])[CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

Product 1

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-538b5da4430f4bb588fb4123818c074b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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