Dichloromethane → 5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide

HRID 2341723Notes

Reaction equation

HRID 2341723 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[s:10][c:11](-[c:14]2[n:15][cH:16][n:17](-[c:19]3[n:20][c:21](-[c:26]4[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]4)[cH:22][c:23]([CH3:25])[n:24]3)[cH:18]2)[cH:12][cH:13]1.[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[NH2:5][S:6](=[O:7])(=[O:8])[c:9]1[s:10][c:11](-[c:14]2[n:15][cH:16][n:17](-[c:19]3[n:20][c:21](-[c:26]4[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]4)[cH:22][c:23]([CH3:25])[n:24]3)[cH:18]2)[cH:12][cH:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57468939N-tert-Butyl-5-{1-[6-(4-chloro-phenyl)-4-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonamide

Product 1

HCID 574689385-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide

Sources & evidence

ORD record
ord-4ec4923dd76e4d90a3374bec406be82d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…