Toluene → Tert-butyl 4-(7-(1-(4-(trifluoromethyl)phenyl)piperidin-4-yloxy)imidazo[1,2-a]pyridine-2-carboxamido)piperidine-1-carboxylate

HRID 2341773Notes

Reaction equation

HRID 2341773 reaction equation
[CH3:77][c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1.[F:41][C:42]([c:43]1[cH:44][cH:45][c:46]([N:49]2[CH2:50][CH2:51][CH:52]([OH:55])[CH2:53][CH2:54]2)[cH:47][cH:48]1)([F:56])[F:57].[O:27]=[C:28]([O:29][CH:30]([CH3:31])[CH3:32])[N:33]=[N:34][C:35]([O:36][CH:37]([CH3:38])[CH3:39])=[O:40].[OH:1][c:2]1[cH:3][c:4]2[n:5]([cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[NH:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]1)[n:10]2.[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[O:1]([c:2]1[cH:3][c:4]2[n:5]([cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[NH:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:18][CH2:19]1)[n:10]2)[CH:52]1[CH2:51][CH2:50][N:49]([c:46]2[cH:45][cH:44][c:43]([C:42]([F:41])([F:56])[F:57])[cH:48][cH:47]2)[CH2:54][CH2:53]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 220976741-[4-(Trifluoromethyl)phenyl]piperidin-4-olHCID 178452117HCID 178452117, compound

Product 1

HCID 57951074Tert-butyl 4-(7-(1-(4-(trifluoromethyl)phenyl)piperidin-4-yloxy)imidazo[1,2-a]pyridine-2-carboxamido)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-70360dafcfc24ee4a93a86fc90740e96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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