Hydrochloric Acid → HCID 86750113, compound

HRID 234233Notes

Reaction equation

HRID 234233 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:42][Si](C)(C)C(C)(C)C(C)C)[C:6]2[CH2:19][S:18][CH2:17][C@@H:16]([C:20]3[O:24][N:23]=[C:22]([CH3:25])[N:21]=3)[NH:15][C:14](=[S:26])[CH2:13][CH2:12][C@@H:11]([CH2:27][O:28][C:29](=[O:38])[C:30]3[CH:35]=[CH:34][C:33]([CH2:36][NH2:37])=[CH:32][CH:31]=3)[CH2:10][O:9][C:8](=[O:39])[C:7]=2[C:40]=1[CH3:41].[F-].[NH4+].[ClH:54]>CO.C(OCC)C>[ClH:54].[OH:42][C:5]1[C:6]2[CH2:19][S:18][CH2:17][C@@H:16]([C:20]3[O:24][N:23]=[C:22]([CH3:25])[N:21]=3)[NH:15][C:14](=[S:26])[CH2:13][CH2:12][C@@H:11]([CH2:27][O:28][C:29](=[O:38])[C:30]3[CH:31]=[CH:32][C:33]([CH2:36][NH2:37])=[CH:34][CH:35]=3)[CH2:10][O:9][C:8](=[O:39])[C:7]=2[C:40]([CH3:41])=[C:3]([O:2][CH3:1])[CH:4]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 25516Ammonium fluorideHCID 57172444HCID 57172444, compound

Product 1

HCID 86750113HCID 86750113, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

4-Aminomethyl-benzoic acid (4R,9S)-14-methoxy-13-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-16-[dimethyl-(1,1,2-trimethylpropyl)-silanyloxy]-12-oxo-6-thioxo-1,3,4,5,6,7,8,9,10,12-decahydro-11,2,5-benzoxathiaazacyclotetradecin-9-ylmethyl ester was treated with ammonium fluoride in methanol in an analogous manner to the procedure described in Example 1, and the resulting product was treated in methanol with a 3N solution of hydrochloric acid in diethyl ether to yield 4-aminomethyl-benzoic acid (4R,9S)-16-hydroxy-14-methoxy-13-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-12-oxo-6-thioxo-1,3,4,5,6,7,8,9,10,12-decahydro-11,2,5-benzoxathiaazacyclotetradecin-9-ylmethyl ester hydrochloride as white solid.

Sources & evidence

ORD record
ord-7204c525d3a44712b7f95ac50afaa8d2
Source dataset
uspto-grants-1997_01
Patent number
US05594135

Reaction notes

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