Tetrahydrofuran → (4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-(5-bromo-2-isopropyl-phenyl)-methanol

HRID 2342547Notes

Reaction equation

HRID 2342547 reaction equation
[Br:24][c:25]1[cH:26][cH:27][c:28]([CH:33]([CH3:34])[CH3:35])[c:29]([CH:30]=[O:31])[cH:32]1.[CH2:19]([Li:20])[CH2:21][CH2:22][CH3:23].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][c:15]([Br:18])[cH:16][cH:17]2.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][O:11][c:12]2[c:13]1[cH:14][c:15]([CH:30]([c:29]1[c:28]([CH:33]([CH3:34])[CH3:35])[cH:27][cH:26][c:25]([Br:24])[cH:32]1)[OH:31])[cH:16][cH:17]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 583408326-bromo-4-(phenylmethyl)-3,4-dihydro-2H-1,4-benzoxazineHCID 583408355-Bromo-2-isopropylbenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 67117055(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-(5-bromo-2-isopropyl-phenyl)-methanol

Sources & evidence

ORD record
ord-d8af1e312807406fb7cddc9ddbeff712
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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