Dimethylformamide → 5-(6-carbamoylmethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-indole-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide

HRID 2342668Notes

Reaction equation

HRID 2342668 reaction equation
[Br:33][CH2:34][C:35](=[O:36])[NH2:37].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[n:1]1[cH:2][n:3][c:4]([O:10][c:11]2[cH:12][c:13]3[cH:14][cH:15][n:16]([C:20](=[O:21])[NH:22][c:23]4[cH:24][c:25]([C:29]([F:30])([F:31])[F:32])[cH:26][cH:27][cH:28]4)[c:17]3[cH:18][cH:19]2)[c:5]2[c:6]1[CH2:7][NH:8][CH2:9]2>>[n:1]1[cH:2][n:3][c:4]([O:10][c:11]2[cH:12][c:13]3[cH:14][cH:15][n:16]([C:20](=[O:21])[NH:22][c:23]4[cH:24][c:25]([C:29]([F:30])([F:31])[F:32])[cH:26][cH:27][cH:28]4)[c:17]3[cH:18][cH:19]2)[c:5]2[c:6]1[CH2:7][N:8]([CH2:34][C:35](=[O:36])[NH2:37])[CH2:9]2

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 696322-BromoacetamideHCID 593944295-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-(3-(trifluoromethyl)phenyl)-1H-indole-1-carboxamide

Product 1

HCID 593947095-(6-carbamoylmethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-indole-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide

Sources & evidence

ORD record
ord-da7fc3c490f8447791321170467580eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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