Tetrahydrofuran → 1-(p-Chlorophenyl)-1-cyclopropyl-2-fluoro-4-(4-fluoro-3-phenoxyphenyl)-1-buten-3-ol
Reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[Cl:22][c:23]1[cH:24][cH:25][c:26]([C:27](=[C:28]([CH:29]=[O:30])[F:31])[CH:32]2[CH2:33][CH2:34]2)[cH:35][cH:36]1.[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1.[O:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][c:15]([CH2:16][Br:17])[cH:18][cH:19][c:20]1[F:21]>>[O:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][c:15]([CH2:16][CH:29]([C:28](=[C:27]([c:26]2[cH:25][cH:24][c:23]([Cl:22])[cH:36][cH:35]2)[CH:32]2[CH2:33][CH2:34]2)[F:31])[OH:30])[cH:18][cH:19][c:20]1[F:21]Participants
5
Sources & evidence
- ORD record
- ord-471c6e5d4755478da3ee9332e1db44bb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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