tert-Butyl methacrylate → Tert-butyl 3-[4-[(4-hydroxyphenyl)-(2,2,6,6-tetramethyloxan-4-ylidene)methyl]phenyl]-2-methylprop-2-enoate

HRID 2343708Notes

Reaction equation

HRID 2343708 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([c:9]2[cH:10][cH:11][c:12]([OH:15])[cH:13][cH:14]2)=[C:16]2[CH2:17][C:18]([CH3:24])([CH3:25])[O:19][C:20]([CH3:22])([CH3:23])[CH2:21]2)[cH:6][cH:7]1.[CH3:26][C:27]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])=[CH2:35].[Pd:36]([Cl:37])[Cl:38].[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1.[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[c:2]1([CH:26]=[C:27]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH3:35])[cH:3][cH:4][c:5]([C:8]([c:9]2[cH:10][cH:11][c:12]([OH:15])[cH:13][cH:14]2)=[C:16]2[CH2:17][C:18]([CH3:24])([CH3:25])[O:19][C:20]([CH3:22])([CH3:23])[CH2:21]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 11448tert-Butyl methacrylateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 686543254-[(4-Bromophenyl)(2,2,6,6-tetramethyltetrahydro-4H-pyran-4-ylidene)methyl]phenol

Product 1

HCID 68975538Tert-butyl 3-[4-[(4-hydroxyphenyl)-(2,2,6,6-tetramethyloxan-4-ylidene)methyl]phenyl]-2-methylprop-2-enoate

Sources & evidence

ORD record
ord-54a60c90993d4bdf84b29f49223c991b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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