3-Bromoanisole → (3-Methoxyphenyl)boronic acid

HRID 234371Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([O:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.[B:10](OC(C)C)([O:15]C(C)C)[O:11]C(C)C>>[CH3:9][O:8][C:4]1[CH:3]=[C:2]([B:10]([OH:15])[OH:11])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 169713-Bromoanisole

HCID 21531Triisopropyl borate

Product 1

HCID 2734370(3-Methoxyphenyl)boronic acidYield 82%

Procedure

3-Methoxyphenylboronic acid was prepared in the same manner as described in Example 33B from 3-bromoanisole and triisopropyl borate in 82% yield. This was used in the next step without any further purification.

Workup

customThis was used in the next step without any further purification

Sources & evidence

ORD record: ord-efdc30be8bf64f399fbb1ec3984f513b
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05594021

Reaction notes

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