Water → 5-(6,7-Dimethoxyquinazolin-4-yloxy)-2,4-difluoroaniline
Reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[Cl:17][c:18]1[n:19][cH:20][n:21][c:22]2[cH:23][c:24]([O:30][CH3:31])[c:25]([O:28][CH3:29])[cH:26][c:27]12.[Cs+:5].[Cs+:6].[NH2:7][c:8]1[c:9]([F:16])[cH:10][c:11]([F:15])[c:12]([OH:14])[cH:13]1.[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[OH2:32]>>[NH2:7][c:8]1[c:9]([F:16])[cH:10][c:11]([F:15])[c:12]([O:14][c:18]2[n:19][cH:20][n:21][c:22]3[cH:23][c:24]([O:30][CH3:31])[c:25]([O:28][CH3:29])[cH:26][c:27]23)[cH:13]1Participants
7
Sources & evidence
- ORD record
- ord-bb6b901bb8a241cb8405bb6338bca494
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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