Benzo(B)Thiophene → MLS002608206

HRID 234403Notes

Reaction equation

HRID 234403 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[CH3:15][N:16]([CH3:25])[C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1>C1COCC1>[S:1]1[C:5]([CH:21]([OH:22])[C:20]2[CH:19]=[CH:18][C:17]([N:16]([CH3:15])[CH3:25])=[CH:24][CH:23]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 74794-(Dimethylamino)BenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 237069MLS002608206

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

α-(2-benzo[b]thienyl)-4-dimethylaminobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi(1.7M, 8.9 mmoles, 5.3 ml), 4-dimethylaminobenzaldehyde (8.9 mmoles, 1.3 g) and THF (20 ml). The crude product (2.4 g) was carried forward without further purification.

Workup

  1. customThe crude product (2.4 g) was carried forward without further purification

Sources & evidence

ORD record
ord-eda2e93f1d7c4169b5e74608a80d9788
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Reaction notes

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