Tetrahydrofuran → (5-Bromo-2-chloro-phenyl)-[1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-quinolin-6-yl]-methanol

HRID 2344975Notes

Reaction equation

HRID 2344975 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[N:8]([CH2:12][c:13]1[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[CH2:7][CH2:6][CH2:5]2.[Br:26][c:27]1[cH:28][cH:29][c:30]([Cl:35])[c:31]([CH:32]=[O:33])[cH:34]1.[CH2:21]([Li:22])[CH2:23][CH2:24][CH3:25].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1>>[c:2]1([CH:32]([c:31]2[c:30]([Cl:35])[cH:29][cH:28][c:27]([Br:26])[cH:34]2)[OH:33])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[N:8]([CH2:12][c:13]1[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]1)[CH2:7][CH2:6][CH2:5]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 106089255-Bromo-2-chlorobenzaldehydeHCID 583408536-Bromo-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-quinolineHCID 178418339Butyllithium

Product 1

HCID 67115847(5-Bromo-2-chloro-phenyl)-[1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-quinolin-6-yl]-methanol

Sources & evidence

ORD record
ord-f72a8d5f739c4e7c8550f1d11d957c81
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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