HRID234507

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(C(=O)OCc2ccccc2)ccc1S(=O)(=O)Cl

HCID15231551

未命名化合物

HCID19076376

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)OCc2ccccc2)ccc1S(=O)(=O)N1C(=O)C(N)(c2ccccc2Cl)c2cc(Cl)ccc21

HCID19076622

未命名化合物

收率 78.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226138

未命名化合物

PROCEDURE

实验过程

This compound is prepared according to the procedure described in EXAMPLE 1 from 0.860 g of 3-amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 1 g of benzyl 4-chlorosulfonyl-3-methoxybenzoate. Chromatography on silica using a DCM/AcOEt mixture (99/1; v/v) as the eluent gives 1.38 g of the expected product, which is used as such in the next step.

WORKUP

后处理

customThis compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a97bad2ebba54401bf66eca606dc1748
来源数据集: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05594023
来源说明: uspto-grants-1997_01

反应 SMILES

[NH2:1][C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].Cl[S:21]([C:24]1[CH:39]=[CH:38][C:27]([C:28]([O:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[O:29])=[CH:26][C:25]=1[O:40][CH3:41])(=[O:23])=[O:22]>C(Cl)Cl.CCOC(C)=O>[NH2:1][C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4]([S:21]([C:24]2[CH:39]=[CH:38][C:27]([C:28]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[O:29])=[CH:26][C:25]=2[O:40][CH3:41])(=[O:23])=[O:22])[C:3]1=[O:12]