HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-chlorosulfonyl-3-methoxybenzoate → Benzyl 4-[3-amino-5-chloro-3-(2-chlorophenyl)-2,3-dihydro-2-oxoindol-1-yl]sulfonyl-3-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-chlorosulfonyl-3-methoxybenzoate | HCID 15231551 | — |
| Reactant | 3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one | HCID 19076376 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | Benzyl 4-[3-amino-5-chloro-3-(2-chlorophenyl)-2,3-dihydro-2-oxoindol-1-yl]sulfonyl-3-methoxybenzoate | HCID 19076622 | 78.7% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 1 from 0.860 g of 3-amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 1 g of benzyl 4-chlorosulfonyl-3-methoxybenzoate. Chromatography on silica using a DCM/AcOEt mixture (99/1; v/v) as the eluent gives 1.38 g of the expected product, which is used as such in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-a97bad2ebba54401bf66eca606dc1748 |
| Source note | uspto-grants-1997_01 |