Acetate → 5-(2-Chloro-5-fluoro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

HRID 2345078Notes

Reaction equation

HRID 2345078 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[Cl:12][c:13]1[n:14][cH:15][c:16]([F:22])[cH:17][c:18]1[B:19]([OH:20])[OH:21].[I:1][c:2]1[c:3]([O:10][CH3:11])[n:4][c:5]([O:8][CH3:9])[n:6][cH:7]1.[Na+:27].[Na+:28].[O-:49][C:50]([CH3:51])=[O:52].[O-:53][C:54]([CH3:55])=[O:56].[Pd+2:48].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[c:2]1(-[c:18]2[c:13]([Cl:12])[n:14][cH:15][c:16]([F:22])[cH:17]2)[c:3]([O:10][CH3:11])[n:4][c:5]([O:8][CH3:9])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 923Sodium ion2×HCID 11776TriphenylphosphineHCID 19660Carbonate IonHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2634165-Iodo-2,4-dimethoxypyrimidineHCID 249017742-Chloro-5-fluoropyridine-3-boronic acid

Product 1

HCID 589942395-(2-Chloro-5-fluoro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

Sources & evidence

ORD record
ord-3d422068c768421cb2936ca3dcac66af
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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