HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-2-nitrobenzenesulphonyl chloride → 3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-1-(4-methoxy-2-nitrobenzenesulfonyl)indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-2-nitrobenzenesulphonyl chloride | HCID 87452 | — |
| Reactant | 3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one | HCID 19076376 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-1-(4-methoxy-2-nitrobenzenesulfonyl)indol-2-one | HCID 19076369 | 81.1% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 1 from 2 g of 3-amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 1.71 g of 4-methoxy-2-nitrobenzenesulfonyl chloride. Chromatography on silica using a DCM/hexane mixture (80/20; v/v) and then DCM as the eluent gives 2.8 g of the expected product after crystallization from a DCM/iso ether mixture. M.p.=192°-195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-e0aea322e42448f881e0e2e4b5e997fc |
| Source note | uspto-grants-1997_01 |