Water → (S)-3-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid

HRID 23453Notes

Reaction equation

HRID 23453 reaction equation
C([O:5][C:6](=[O:20])[CH2:7][C@@:8]([OH:19])([CH2:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][CH:15]=1)[CH:9]([CH3:11])[CH3:10])(C)(C)C.[Li+].[OH-].O>CO>[OH:19][C@:8]([CH2:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][CH:15]=1)([CH:9]([CH3:10])[CH3:11])[CH2:7][C:6]([OH:20])=[O:5]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 11141066(S)-3-hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic acid tert-butyl ester

Product 1

HCID 11831610(S)-3-Hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic Acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared as described in General Method 10 using (S)-3-hydroxy-4-methyl-3-(2-thiophen-3-yl-ethyl)-pentanoic acid tert-butyl ester (Example F-1 (S); 8 mmol), LiOH (16 mmol), H2O (5 mL), and MeOH (15 mL).

Sources & evidence

ORD record
ord-9865ed45cc664d3d983a8348d200aeb3
Source dataset
uspto-grants-2005_02
Patent number
US06852711B2

Reaction notes

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