Ethyl Acetate → 1,2-dimethyl-6-(2-[3-methoxy-pyrrolidine-1-carbonyl]thieno[3,2-b]pyridin-7-yloxy)-1H-indole-3-carboxylic acid methylamide

HRID 2345357Notes

Reaction equation

HRID 2345357 reaction equation
[C:36](=[O:37])([O-:38])[O-:39].[CH3:20][NH:21][C:22](=[O:23])[c:24]1[c:25]([CH3:35])[n:26]([CH3:34])[c:27]2[cH:28][c:29]([OH:33])[cH:30][cH:31][c:32]12.[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[N:13]1[CH2:14][CH:15]([O:18][CH3:19])[CH2:16][CH2:17]1)[s:10]2.[Cs+:40].[Cs+:41]>>[c:2]1([O:33][c:29]2[cH:28][c:27]3[n:26]([CH3:34])[c:25]([CH3:35])[c:24]([C:22]([NH:21][CH3:20])=[O:23])[c:32]3[cH:31][cH:30]2)[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[N:13]1[CH2:14][CH:15]([O:18][CH3:19])[CH2:16][CH2:17]1)[s:10]2

Participants

6

Reactant 5

HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 22143527(3-Methoxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanoneHCID 221435306-hydroxy-N,1,2-trimethyl-1H-indole-3-carboxamide

Product 1

HCID 100507581,2-dimethyl-6-(2-[3-methoxy-pyrrolidine-1-carbonyl]thieno[3,2-b]pyridin-7-yloxy)-1H-indole-3-carboxylic acid methylamide

Sources & evidence

ORD record
ord-a449d7e3e44946b2bdbd4913b71c3e35
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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