HRID234542

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19076401

未命名化合物

结构：COCCCNC1(c2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21

HCID19076606

未命名化合物

PRODUCTS

生成物

结构：COCCCNC1(c2ccccc2Cl)C(=O)N(S(=O)(=O)c2ccc3c(c2)CCN3C(=O)OC)c2ccc(Cl)cc21

HCID19076537

未命名化合物

收率 69.8%

PROCEDURE

实验过程

This compound is prepared according to the procedure described in EXAMPLE 222 from 1.3 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one and 0.980 g of 1-(methoxycarbonyl)indoline-5-sulfonyl chloride. 1.5 g of the expected product are obtained after crystallization from a DCM/iso ether/hexane mixture. M.p.=98° C.

WORKUP

后处理

customThis compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c1b1f3cd0b4484fa926557031e48aac
来源数据集: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05594023
来源说明: uspto-grants-1997_01

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Cl:24])[NH:12][CH2:13][CH2:14][CH2:15][O:16][CH3:17].[CH3:25][O:26][C:27]([N:29]1[C:37]2[C:32](=[CH:33][C:34]([S:38](Cl)(=[O:40])=[O:39])=[CH:35][CH:36]=2)[CH2:31][CH2:30]1)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:38]([C:34]1[CH:33]=[C:32]3[C:37](=[CH:36][CH:35]=1)[N:29]([C:27]([O:26][CH3:25])=[O:28])[CH2:30][CH2:31]3)(=[O:39])=[O:40])[C:6](=[O:11])[C:5]2([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[Cl:24])[NH:12][CH2:13][CH2:14][CH2:15][O:16][CH3:17]