HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Methoxycarbonyl)indoline-5-sulfonyl chloride → 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-1-[[1-(methoxycarbonyl)indolin-5-yl]sulfonyl]-3-[(3-methoxypropyl)amino]indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Methoxycarbonyl)indoline-5-sulfonyl chloride | HCID 19076401 | — |
| Reactant | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one | HCID 19076606 | — |
| Product | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-1-[[1-(methoxycarbonyl)indolin-5-yl]sulfonyl]-3-[(3-methoxypropyl)amino]indol-2-one | HCID 19076537 | 69.8% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 222 from 1.3 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one and 0.980 g of 1-(methoxycarbonyl)indoline-5-sulfonyl chloride. 1.5 g of the expected product are obtained after crystallization from a DCM/iso ether/hexane mixture. M.p.=98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-3c1b1f3cd0b4484fa926557031e48aac |
| Source note | uspto-grants-1997_01 |