反应详情

In a 50 ml-three-necked flask, 1.00 g (3.80 mM) of N-(4-hexylbenzoyl)glycine and 19 ml of dry benzene were placed. To the mixture, 0.53 ml (3.81 mM) of triethylamine was added at room temperature under stirring, followed by addition of 0.37 ml (3.87 mM) of ethyl chloroformate and further stirring for 20 minutes at room temperature to precipitate triethylamine hydrochloride. The resultant hydrochloride was filtered off and the solvent of the filtrate was distilled off. The residue was dried under reduced pressure to obtain 2-(4-hexylphenyl)-5-oxazolone.

1. stirringfurther stirring for 20 minutes at room temperature
2. customto precipitate triethylamine hydrochloride
3. filtrationThe resultant hydrochloride was filtered off
4. distillationthe solvent of the filtrate was distilled off
5. customThe residue was dried under reduced pressure