Hydrochloric Acid → 1-[2-(3-Fluorophenoxy)phenyl]-5-methoxy-1-piperidin-3-ylpentan-1-ol

HRID 2345997Notes

Reaction equation

HRID 2345997 reaction equation
[CH3:39][C:40]#[N:41].[ClH:36].[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[c:7]([C:12]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH3:18])([OH:19])[CH:20]3[CH2:21][N:22]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:23][CH2:24][CH2:25]3)[cH:8][cH:9][cH:10][cH:11]2)[cH:33][cH:34][cH:35]1.[Na+:38].[OH-:37]>>[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[c:7]([C:12]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH3:18])([OH:19])[CH:20]3[CH2:21][NH:22][CH2:23][CH2:24][CH2:25]3)[cH:8][cH:9][cH:10][cH:11]2)[cH:33][cH:34][cH:35]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 6342AcetonitrileHCID 68414326Tert-butyl 3-[1-[2-(3-fluorophenoxy)phenyl]-1-hydroxy-5-methoxypentyl]piperidine-1-carboxylate

Product 1

HCID 684126151-[2-(3-Fluorophenoxy)phenyl]-5-methoxy-1-piperidin-3-ylpentan-1-ol

Sources & evidence

ORD record
ord-5211bbdcf7c348d6af18c85ce6701fb8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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