2-Amino-2-methyl-1-propanol → 2-(4-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-[1,2,3]triazol-1-yl)-N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide

HRID 2346044Notes

Reaction equation

HRID 2346044 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([NH:5][c:6]2[cH:7][cH:8][c:9]([F:10])[cH:11][c:12]2[F:13])[cH:14][cH:15][c:16]1[C:17]([c:18]1[cH:19][c:20](-[c:21]2[n:22][n:23][n:24]([CH2:25][C:26]([NH:27][CH2:28][CH3:29])=[O:30])[cH:31]2)[cH:32][cH:33][c:34]1[CH3:35])=[O:36].[Cl:37][c:38]1[c:39]([C:40](=[O:41])[c:42]2[cH:43][c:44](-[c:49]3[n:50][n:51][n:52]([CH2:54][C:55](=[O:56])[OH:57])[cH:53]3)[cH:45][cH:46][c:47]2[CH3:48])[cH:58][cH:59][c:60]([NH:62][c:63]2[c:64]([F:70])[cH:65][c:66]([F:69])[cH:67][cH:68]2)[cH:61]1.[NH2:71][C:72]([CH2:73][OH:74])([CH3:75])[CH3:76]>>[Cl:37][c:38]1[c:39]([C:40](=[O:41])[c:42]2[cH:43][c:44](-[c:49]3[n:50][n:51][n:52]([CH2:54][C:55](=[O:56])[NH:71][C:72]([CH2:73][OH:74])([CH3:75])[CH3:76])[cH:53]3)[cH:45][cH:46][c:47]2[CH3:48])[cH:58][cH:59][c:60]([NH:62][c:63]2[c:64]([F:70])[cH:65][c:66]([F:69])[cH:67][cH:68]2)[cH:61]1

Participants

4

Reactant 3

HCID 118072-Amino-2-methyl-1-propanolHCID 11496723(4-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-[1,2,3]triazol-1-yl)-acetic acidHCID 115986752-(4-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-[1,2,3]triazol-1-yl)-N-ethyl-acetamide

Product 1

HCID 116064512-(4-{3-[2-Chloro-4-(2,4-difluoro-phenylamino)-benzoyl]-4-methyl-phenyl}-[1,2,3]triazol-1-yl)-N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide

Sources & evidence

ORD record
ord-aea3a20ec34a4fed91c34305ae6f5e43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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