Lithium Bromide → HCID 15813330, compound
Reaction equation
[Br-:1].[Li+].C1(C)C=CC(S([CH:12]([C@:14]2([O:28][CH2:27][C@@H:21]([O:22][C:23](=[O:26])[NH:24][CH3:25])[C@@H:18]([O:19][CH3:20])[C@@:16]2([C:29]([CH3:31])=[CH2:30])[OH:17])[OH:15])O)(=O)=O)=CC=1>CC(C)=O>[Br:1][CH2:12][C@:14]1([O:28][CH2:27][C@@H:21]([O:22][C:23](=[O:26])[NH:24][CH3:25])[C@@H:18]([O:19][CH3:20])[C@@:16]1([C:29]([CH3:31])=[CH2:30])[OH:17])[OH:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 75 °C
Procedure
0.29 g (3.34 mmol) of lithium bromide is added at room temperature, in a single portion, to a solution of 0.31 g (0.69 mmol) of the compound obtained in Example 10 in 15 ml of acetone. The reaction mixture is placed under stirring and then heated at 75° C. for 1.5 hours. A further 0.26 g (2.99 mmol) of lithium bromide is then added and the whole is again heated at 75° C. for one hour. The acetone is evaporated off under reduced pressure and the residue is taken up in 20 ml of ethyl acetate. Customary treatment of the organic phase yields 0.23 g (0.65 mmol) of the desired product in the form of a white-coloured foam.
Workup
- temperaturethe whole is again heated at 75° C. for one hour
- customThe acetone is evaporated off under reduced pressure
Sources & evidence
- ORD record
- ord-d9a6323ec63b4457b265a53c94911d96
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05595976
Reaction notes
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