反应详情

Hydrazine monohydrate (65 ml) was added dropwise to a solution of methyl 1-methyl-1H-pyrrole-2-acetate (0.326 mol) in ethanol (300 ml) and the mixture was refluxed for 4 hours. The mixture was evaporated till dryness. The residue was taken up in dichloromethane and an aqueous potassium carbonate solution (10%) and extracted with dichloromethane. The organic layer was dried (MgSO4) and evaporated. The residue (48.8 g) was taken up in 1,1'-oxybisethane and the precipitate was filtered off, yielding 45.3 g (90%) of 1-methyl-1H-pyrrole-2-acetic acid, hydrazine (interm. 7).

1. temperaturethe mixture was refluxed for 4 hours
2. customThe mixture was evaporated till dryness
3. extractionan aqueous potassium carbonate solution (10%) and extracted with dichloromethane
4. dry with materialThe organic layer was dried (MgSO4)
5. customevaporated
6. filtrationthe precipitate was filtered off