反应详情

3.8 g (20 mmol) of 4-chloro-5-methoxy-6-methoxymethylpyrimidine (DE-A 4 116 089), 3.1 g (20 mmol) of 4-iso-butylidene-cyclohexylamine and 3.0 g (30 mmol) of triethylamine were stirred for 3 hours without solvent at 80°-90° C. After cooling, the mixture was taken up in water/toluene, and the organic phase was dried and evaporated on a rotary evaporator. Purification by chromatography (silica gel/ethyl acetate) gave 2.2 g (36% of theory) of a virtually colorless oil.

1. temperatureAfter cooling
2. customthe organic phase was dried
3. customevaporated on a rotary evaporator
4. customPurification by chromatography (silica gel/ethyl acetate)
5. customgave 2.2 g (36% of theory) of a virtually colorless oil