Dichloromethane → 2,6-difluoro-N-{2-fluoro-3-[5-(2-methyl-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

HRID 2346565Notes

Reaction equation

HRID 2346565 reaction equation
[Cl:52][CH2:53][Cl:54].[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:44])[c:15](-[c:19]3[n:20][c:21]([CH:31]4[CH2:32][CH2:33][N:34]([C:37]([O:38][C:39]([CH3:40])([CH3:41])[CH3:42])=[O:43])[CH2:35][CH2:36]4)[s:22][c:23]3-[c:24]3[n:25][c:26]([CH3:30])[n:27][cH:28][cH:29]3)[cH:16][cH:17][cH:18]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[F:45][C:46]([F:47])([F:48])[C:49]([OH:50])=[O:51]>>[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:44])[c:15](-[c:19]3[n:20][c:21]([CH:31]4[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]4)[s:22][c:23]3-[c:24]3[n:25][c:26]([CH3:30])[n:27][cH:28][cH:29]3)[cH:16][cH:17][cH:18]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 579896871,1-Dimethylethyl 4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate

Product 1

HCID 579899472,6-difluoro-N-{2-fluoro-3-[5-(2-methyl-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Sources & evidence

ORD record
ord-159ef6e064074e46b6625aa459a289fd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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