Tributylphosphine → {6-[2-(4-Trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][c:14]([OH:17])[cH:15][c:16]12)=[O:18].[CH2:36]([P:37]([CH2:38][CH2:39][CH2:40][CH3:41])[CH2:42][CH2:43][CH2:44][CH3:45])[CH2:46][CH2:47][CH3:48].[F:19][C:20]([c:21]1[cH:22][cH:23][c:24](-[c:27]2[s:28][c:29]([CH2:32][OH:33])[cH:30][n:31]2)[cH:25][cH:26]1)([F:34])[F:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([CH2:7][n:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:32][c:29]3[s:28][c:27](-[c:24]4[cH:23][cH:22][c:21]([C:20]([F:19])([F:34])[F:35])[cH:26][cH:25]4)[n:31][cH:30]3)[cH:15][c:16]12)=[O:18]Participants
4
Sources & evidence
- ORD record
- ord-c22c65d303fc4af3b979ddb96929c143
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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