Dimethyl Carbonate → [2-[Isobutyl-(4-trifluoromethyl-phenyl)-amino]-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-acetic acid methyl ester

HRID 2346818Notes

Reaction equation

HRID 2346818 reaction equation
[CH2:9]([CH:10]([CH3:11])[CH3:12])[N:13]([c:14]1[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]1)[c:24]1[n:25][c:26](-[c:31]2[cH:32][cH:33][c:34]([C:37]([F:38])([F:39])[F:40])[cH:35][cH:36]2)[cH:27][c:28]([CH3:30])[cH:29]1.[CH3:2][CH:3]([N-:4][CH:5]([CH3:6])[CH3:7])[CH3:8].[CH3:41][O:42][C:43](=[O:44])[O:45][CH3:46].[Li+:1]>>[CH2:9]([CH:10]([CH3:11])[CH3:12])[N:13]([c:14]1[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]1)[c:24]1[n:25][c:26](-[c:31]2[cH:32][cH:33][c:34]([C:37]([F:38])([F:39])[F:40])[cH:35][cH:36]2)[cH:27][c:28]([CH2:30][C:43]([O:42][CH3:41])=[O:44])[cH:29]1

Participants

5

Reactant 4

HCID 12021Dimethyl CarbonateHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 59161710Isobutyl-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-(4-trifluoromethyl-phenyl)-amine

Product 1

HCID 59161714[2-[Isobutyl-(4-trifluoromethyl-phenyl)-amino]-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-acetic acid methyl ester

Sources & evidence

ORD record
ord-1fbab5a6c6b749e8a0a8d43062e97dce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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