HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Chloro-N-[3-(1-pyrrolidinyl)propyl]-4-quinolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | 1-Pyrrolidinepropanamine | HCID 31670 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Product | 7-Chloro-N-[3-(1-pyrrolidinyl)propyl]-4-quinolinamine | HCID 23355218 | — |
Reaction Steps
3.08 g from 7.72 g of 4,7-dichloroquinoline and 5 g of 3-(pyrrolidin-1-yl)-propylamine (reaction duration 16 hours at 140° C.); the base was converted with isopropanolic hydrochloric acid into the dihydrochloride which when recrystallized from acetonitrile/ethanol, yielded colourless crystals, m.p.: 204°-206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05596002 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-5a5d399323a44fa3b525d97b27c0e024 |
| Source note | uspto-grants-1997_01 |