Dimethyl Sulfoxide → 1-(8-Piperidin-4-yl-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-5,5-dimethylimidazolidin-2,4-dione

HRID 2346867Notes

Reaction equation

HRID 2346867 reaction equation
[CH3:1][C:2]1([CH3:36])[C:3](=[O:35])[NH:4][C:5](=[O:34])[N:6]1[c:7]1[s:8][c:9]2[c:10]([n:33]1)-[c:11]1[c:12]([cH:16][c:17]([CH:20]3[CH2:21][CH2:22][N:23]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:24][CH2:25]3)[cH:18][cH:19]1)[O:13][CH2:14][CH2:15]2.[CH3:37][S:38]([CH3:39])=[O:40].[Cl:48][CH2:49][Cl:50].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[CH3:1][C:2]1([CH3:36])[C:3](=[O:35])[NH:4][C:5](=[O:34])[N:6]1[c:7]1[s:8][c:9]2[c:10]([n:33]1)-[c:11]1[c:12]([cH:16][c:17]([CH:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)[cH:18][cH:19]1)[O:13][CH2:14][CH2:15]2

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58204137tert-butyl 4-(2-(5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-8-yl)-tetrahydropyridine-1(2H)-carboxylate

Product 1

HCID 582042061-(8-Piperidin-4-yl-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-5,5-dimethylimidazolidin-2,4-dione

Sources & evidence

ORD record
ord-c7f29907cdf149bbad36fbcaa7bedd9c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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