4,7-Dichloroquinoline → (RS)-(7-Chloro-quinolin-4-yl)-(1-methyl-piperidin-3-yl)-amine

HRID 234688Notes

Reaction equation

HRID 234688 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][N:16]([CH3:20])[CH2:15]1>C(#N)C>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][CH:14]3[CH2:19][CH2:18][CH2:17][N:16]([CH3:20])[CH2:15]3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 68664,7-DichloroquinolineHCID 38609711-Methylpiperidin-3-amine

Product 1

HCID 23355213(RS)-(7-Chloro-quinolin-4-yl)-(1-methyl-piperidin-3-yl)-amine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4 g from 11.29 g of 4,7-dichloroquinoline and 6.5 g of 3-amino-1-methyl-piperidine; colourless crystals from acetonitrile, m.p.: 149°-150° C.

Sources & evidence

ORD record
ord-044c76ac0a4c43a19733f98fe773dfa1
Source dataset
uspto-grants-1997_01
Patent number
US05596002

Reaction notes

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