反应详情

温度

140 °C

83.9 g of 7-chloro-4-hydroxyquinoline were added portionwise at 60° to 150 g of phosphorus oxybromide and the mixture was thereafter heated to 140° C. for 6 hours. After cooling, the mixture was treated with 3 l of ice-water and extracted with 2×1.5 l of dichloromethane. After evaporation of the solvent and crystallization from 1.3 l of hexane, 34 g of product were obtained as colourless crystals, m.p.: 102°-103° C.

1. temperatureAfter cooling
2. extractionextracted with 2×1.5 l of dichloromethane
3. customAfter evaporation of the solvent and crystallization from 1.3 l of hexane