Sodium Hydroxide → HCID 10379653, compound

HRID 234705Notes

Reaction equation

HRID 234705 reaction equation
[C:1]1([C:7]([CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][CH2:10]2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH-].[Na+]>C(Cl)Cl>[C:1]1([C:7]([CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:11][CH2:10]2)=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14257839HCID 14257839, compound

Product 1

HCID 10379653HCID 10379653, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Mix phenyl[1-(2-phenylethyl)-4-piperidinyl]methanone·HCl (5.0g, 15.16mmol), 1N sodium hydroxide (100mL) and methylene chloride (250mL) and stir overnight at room temperature. Separate the organic phase and extract the aqueous phase with methylene chloride. Combine the organic phases, dry (MgSO4) and evaporate the solvent in vacuo to give phenyl[1-(2-phenylethyl)-4-piperidinyl]methanone.

Workup

  1. customSeparate the organic phase
  2. extractionextract the aqueous phase with methylene chloride
  3. dry with materialdry (MgSO4)
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-d9612964958141759866b83a38c87061
Source dataset
uspto-grants-1997_01
Patent number
US05596003

Reaction notes

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