Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2347244Generated: October 31, 2026

Tetrahydrofuran → (RS)-(4-cyano-phenylamino)-{5-ethoxy-2-fluoro-3-[1-(2-hydroxy-ethyl)-piperidin-4-yloxy]-phenyl}acetic acid ethyl ester

https://huagongshe.com/reaction/2347244

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantTriethylamineHCID 8471—
Reactant2-BromoethanolHCID 10898—
ReactantTetrabutylammoniumHCID 16028—
ReactantIodide IonHCID 30165—
Reactant(RS)-(4-cyano-phenylamino)-[5-ethoxy-2-fluoro-3-(piperidin-4-yloxy)-phenyl]-acetic acid ethyl esterHCID 69923727—
Product(RS)-(4-cyano-phenylamino)-{5-ethoxy-2-fluoro-3-[1-(2-hydroxy-ethyl)-piperidin-4-yloxy]-phenyl}acetic acid ethyl esterHCID 69924307—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (10/10)
ORD IDord-fdbf1815cc7a4460a3d2033d35775117
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (10/10)