Tetrahydrofuran → (RS)-(4-cyano-phenylamino)-{5-ethoxy-2-fluoro-3-[1-(2-hydroxy-ethyl)-piperidin-4-yloxy]-phenyl}acetic acid ethyl ester
Reaction equation
[Br:40][CH2:41][CH2:42][OH:43].[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([c:6]1[c:7]([F:22])[c:8]([O:15][CH:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[cH:9][c:10]([O:12][CH2:13][CH3:14])[cH:11]1)[NH:23][c:24]1[cH:25][cH:26][c:27]([C:30]#[N:31])[cH:28][cH:29]1)=[O:32].[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH2:50]([N+:51]([CH2:52][CH2:53][CH2:54][CH3:55])([CH2:56][CH2:57][CH2:58][CH3:59])[CH2:60][CH2:61][CH2:62][CH3:63])[CH2:64][CH2:65][CH3:66].[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[I-:49]>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([c:6]1[c:7]([F:22])[c:8]([O:15][CH:16]2[CH2:17][CH2:18][N:19]([CH2:41][CH2:42][OH:43])[CH2:20][CH2:21]2)[cH:9][c:10]([O:12][CH2:13][CH3:14])[cH:11]1)[NH:23][c:24]1[cH:25][cH:26][c:27]([C:30]#[N:31])[cH:28][cH:29]1)=[O:32]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-fdbf1815cc7a4460a3d2033d35775117
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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