Tetrahydrofuran → 5-fluoro-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH2:18][CH2:19][O:20][CH3:21])[c:7](-[c:9]3[cH:10][cH:11][c:12]([CH:15]([CH3:16])[CH3:17])[cH:13][cH:14]3)[n:8]2)[c:22]([O:24][CH3:25])[cH:23]1.[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:26][CH2:27][CH2:28][CH2:29][Li:30].[F:31][N:32]([S:33]([c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)(=[O:40])=[O:41])[S:42]([c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)(=[O:49])=[O:50]>>[c:2]1([F:31])[cH:3][c:4]2[c:5]([n:6]([CH2:18][CH2:19][O:20][CH3:21])[c:7](-[c:9]3[cH:10][cH:11][c:12]([CH:15]([CH3:16])[CH3:17])[cH:13][cH:14]3)[n:8]2)[c:22]([O:24][CH3:25])[cH:23]1Participants
5
Sources & evidence
- ORD record
- ord-9d97ead2d32c4531b6ebd383f523f923
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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