反应详情

6-tert-Butyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (Prepared in Example HH; 12.0 g) in CH2Cl2 (100 mL) was cooled to 0° C. and treated with HCl gas for 10 minutes. The reaction mixture was warmed to room temperature and stirred for 1 hour. The solvents were evaporated; the residue was dissolved in EtOAc, washed with saturated NaHCO3 solution and brine, and dried (MgSO4.) Concentration gave the title compound which was used without any further purification. MS(APCI): 176 (M+H).

1. customwas cooled to 0° C.
2. customThe solvents were evaporated
3. dissolutionthe residue was dissolved in EtOAc
4. washwashed with saturated NaHCO3 solution and brine
5. customdried
6. concentration(MgSO4.) Concentration