HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 234770Generated: October 25, 2026
Water → Methyl 4-hydroxy-3-[(hydroxyimino)methyl]benzoate
https://huagongshe.com/reaction/234770
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzoic acid, 3-formyl-4-hydroxy-, methyl ester | HCID 212595 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-hydroxy-3-[(hydroxyimino)methyl]benzoate | HCID 136381071 | 80.7% |
Reaction Steps
A solution of 68.0 g (0.83 mol) of sodium acetate and 68.0 g (0.98 mol) of hydroxylamine hydrochloride in. 300 ml of water is added dropwise to a solution of 80.5 g (0.45 mol) of 2-hydroxy-5-methoxycarbonylbenzaldehyde in 300 ml of methanol and the mixture is stirred at 25° C. for 2 hours. The product which has precipitated is filtered off with suction, washed with water and dried in vacuo over phosphorus pentoxide to give 70.4 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05596006 |
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| Source dataset | uspto-grants-1997_01 |
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| ORD ID | ord-c6436de8a30840388dc8cea6e402ba7b |
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| Source note | uspto-grants-1997_01 |
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