Water → Methyl 4-hydroxy-3-[(hydroxyimino)methyl]benzoate

HRID 234770노트

반응식

HRID 234770 반응식
C([O-])(=O)C.[Na+].Cl.[NH2:7][OH:8].O.[OH:10][C:11]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][C:12]=1[CH:13]=O>CO>[OH:10][C:11]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][C:12]=1[CH:13]=[N:7][OH:8]

참가 물질

6

반응물 4

HCID 962WaterHCID 212595Benzoic acid, 3-formyl-4-hydroxy-, methyl esterHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 136381071Methyl 4-hydroxy-3-[(hydroxyimino)methyl]benzoate수율 80.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

A solution of 68.0 g (0.83 mol) of sodium acetate and 68.0 g (0.98 mol) of hydroxylamine hydrochloride in. 300 ml of water is added dropwise to a solution of 80.5 g (0.45 mol) of 2-hydroxy-5-methoxycarbonylbenzaldehyde in 300 ml of methanol and the mixture is stirred at 25° C. for 2 hours. The product which has precipitated is filtered off with suction, washed with water and dried in vacuo over phosphorus pentoxide to give 70.4 g of the title compound.

후처리

  1. customThe product which has precipitated
  2. filtrationis filtered off with suction
  3. washwashed with water
  4. dry with materialdried in vacuo over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-c6436de8a30840388dc8cea6e402ba7b
출처 데이터셋
uspto-grants-1997_01
특허 번호
US05596006

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